Install
# Ubuntu: install additional packages required for DESeq2
sudo apt-get install libxml2-dev
sudo apt-get install libcurl4-openssl-dev
# install DESeq2 from Bioconductor.org
sudo R # start R as superuser
> source("http://bioconductor.org/biocLite.R")
> biocLite("DESeq2")
http://bioconductor.org/packages/release/bioc/html/DESeq2.html